OPSYNVI® Is a Once-Daily Pill With a Dual-Pathway Approach

Discover a combination therapy that targets two foundational PAH pathways.

Starting OPSYNVI®

If you are not currently on any PAH therapy or are transitioning
from an ERA alone:

Starting dose of OPSYNVI® pill

One OPSYNVI® pill (macitentan 10mg/tadalafil 20mg), once daily for 1 week.

OPSYNVI® pill made up of macitentan and tadalafil

If tolerated, the doctor will increase your dose to one OPSYNVI® pill (macitentan 10mg/tadalafil 40mg), once daily.

ERA = endothelin receptor antagonist

If you are transitioning from a PDE5i alone or taking the combination of an ERA and a PDE5i as individual pills:

OPSYNVI® pill made up of macitentan and tadalafil

Start with one OPSYNVI® pill (macitentan 10mg/tadalafil 40mg), once daily.

PDE5i = phosphodiesterase type 5 inhibitor

The pills illustrated above are not actual size.

How to Take OPSYNVI®

Once you and your healthcare provider decide that OPSYNVI® is right for you, OPSYNVI® will be mailed to you by a specialty pharmacy.

  • Take OPSYNVI® exactly as instructed by your healthcare provider. Do not stop taking OPSYNVI® unless your healthcare provider tells you to do so.
  • OPSYNVI® is an oral pill of macitentan
    10-mg/tadalfil 40-mg taken once daily by mouth.
  • OPSYNVI® can be taken with or without food.
  • Take the pill whole and do not cut, crush, or chew OPSYNVI® pills.
  • If you accidentally take too much OPSYNVI®, contact your healthcare provider or go to the nearest hospital emergency room right away.
  • If you miss a dose of OPSYNVI®, take it as soon as you remember that day. Take the next dose at your regular time. Do not take 2 doses at the same time to make up for a missed dose.

Learn How OPSYNVI® Can Help You Manage Your PAH

Download the OPSYNVI® brochure for quick access to the benefits and patient support options available to you.

Download Brochure Download resource
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